B cells: AID provided by RPA

Comparison of benefits provided by different hearing aid technologies.

The performance of 40 hearing-impaired adults with the GN ReSound digital BZ5 hearing instrument was compared with performance with linear hearing aids with input compression limiting (AGC-I) or two-channel analog wide dynamic range compression (WDRC) instruments. The BZ5 was evaluated with an omnidirectional microphone, dual-microphone directionality, and a noise reduction circuit in combinati...

AID-Expressing Germinal Center B Cells

Differential Programming of B Cells in AID Deficient Mice

The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes. Besides these Ig specific activities in B cells, AID has been implicated in active DNA demethylation in non-B cell systems. We here determined a potential role of...

UNG protects B cells from AID-induced telomere loss

Activation-induced deaminase (AID) initiates antibody gene diversification by creating G:U mismatches in the immunoglobulin loci. However, AID also deaminates nonimmunoglobulin genes, and failure to faithfully repair these off-target lesions can cause B cell lymphoma. In this study, we identify a mechanism by which processing of G:U produced by AID at the telomeres can eliminate B cells at risk...

AID overwhelms Polβ in class-switching B cells

The immune system takes its cues from antigen-presenting cells (APCs) to either go on the offensive against a foreign enemy or to stand down and tolerate a harmless threat. Ehirchiou et al. (page 1519) now report a new mechanism by which APCs power down the immune system: an APC surface receptor suppresses the development of overzealous T helper (Th)-17 cells. According to dogma, APCs that have...